Wilm's Tumor 1 (WT1) (Wilm's Tumor & Mesothelial Marker) MBS439717 from MyBioSource.com

Product Specs
ItemWilm's Tumor 1 (WT1) (Wilm's Tumor & Mesothelial Marker)
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS439717
Quantity0.1 mg
ApplicationsFlow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin
ConcentrationPurified Ab with BSA and Azide at 200ug/ml
Conjugate/TagUnconjugated
Format200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 1mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml
ReactivityHuman, Mouse, Rat
TargetWilm's Tumor 1
IsotypeIgG
Molecular WeightAntigen: 47-55kDa
CloneWT1/857 + 6F-H2
HostMouse
ImmunogenRecognizes a 47-55kDa-tumor suppressor protein, identified as Wilms tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilms tumors. WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilms tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilms tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas
NCBI Full Gene NameWilms tumor 1
NCBI Gene AliasesWIT-2, EWS-WT1, GUD, WAGR, AWT1, NPHS4, WT33
ClonalityMonoclonal